This study aims to identify the relationship between the level of psychological flourishing and marital happiness among mothers of autistic children enrolled in educational institutions in Najran, KSA, and the extent of their level of psychological flourishing and marital happiness according to the variables of the mother’s educational level, the mother’s work, and the number of years of marriage. The study sample consisted of (80) mothers of autistic children enrolled in learning centers. The descriptive approach was followed, and its tools were the psychological flourishing scale written by Diener et al (2010), and the marital happiness scale written by Muhammad Al-Mahdi (2014). The study revealed the following results: the level of psychological flourishing among mothers of autistic children attending learning centers is high, and their level of marital happiness is very high. The results also showed that there are no statistically significant differences in the level of psychological flourishing among mothers of autistic children enrolled in learning centers in the Najran region due to the variables of the mother’s educational level, the mother’s work, and the number of years of marriage; there are statistically significant differences in the level of marital happiness among mothers of autistic children enrolled in learning centers in the Najran region due to the variable of the mother’s educational level, and there are no statistically significant differences in the level of marital happiness among mothers of autistic children enrolled in learning centers in the Najran region due to the variables of the mother’s work and number of years of marriage. (Published abstract)